化学英文文献翻译AbstractCu(BZA)2(EtOH)0.5(1)was generated by the rea

化学英文文献翻译
Abstract
Cu(BZA)2(EtOH)0.5(1)was generated by the reaction of copper(II hydroxide with benzoic acid(BZAH).[Cu(TBZH)2(BZA)]-
(BZA·0.5TBZH．H2O(2)and[Cu(2-PyBZIMH)(2-PyBZIM)(BZA)]·1.66EtOH(3)were obtained when 1 reacted with Thiabendazole
(TBZH)and 2-(2-pyridyl)benzimidazole(2-PyBZIMH),respectively.[Cu(BZA)2(phen)(H2O)](4)was isolated from the reaction of ben-
zoic acid and 1,10-phenanthroline(phen)with copper(II)acetate dihydrate.Molecular structures of 2,3 and 4 were determined crystal-
lographically.2 and 3 are hydrogen bonded dimers and trimers,respectively.The copper centres in complexes 2 and 3 are bis-chelate derivatives that have N4O ligation and their geometry is very similar being approximately square-pyramidal.However whereas in complex 2 both TBZH ligands are neutral in 3 one of the 2-PyBZIMH chelators is deprotonated on each copper.The structural results for 4 represent a re-examination of this crystallographically known compound for which no hydrogen atom coordinates have been previously reported.It crystallises as a hydrogen bonded dimmer and is a mono-chelate of phen with each copper centre possessing N2O3 ligation and square pyramidal geometry.The catalase and superoxide dismutase(SOD)activities of the four complexes along with those of the known phenanthroline complexes[Cu(mal)(phen)2]and[Cu(phendione)3](ClO4)2(malH2=malonic acid and phendione=1,10-phenan-throline-5,6-dione)were investigated.Complexes 1–4,the metal free ligands and a simple copper(II)salt were assessed for their cancer chemotherapeutic potential against the hepatocellular carcinoma(Hep-G2)and kidney adenocarcinoma(A-498)cell lines.TBZH,2-PyB-ZIMH and benzoic acid when uncoordinated to a metal centre offer poor chemotherapeutic potential.copper(II)benzoate is significantlymore active than the free acid.The bis-chelate derivatives[Cu(TBZH)2(BZA)](BZA·0.5TBZH·H2O(2)a nd[Cu(2-PyBZIMH)(2-PyB-ZIM)(BZA)]·1.66EtOH(3)elicit a significant cytotoxic response to the cancer cell lines tested.Replacing TBZH and 2-PyBZIMH with phen to give[Cu(BZA)2(phen)(H2O)](4)does not significantly increase the anti-cancer activity.
2007 Elsevier Inc.All rights reserved.
1.Introduction
Cancer,of which there are over 100 di?erent forms,is a leading cause of death.The clinical success of cisplatin,and related platinum based drugs,as anti-cancer agents constitutes the most impressive contribution to the use of metals in medicine[1].However major problems associated with these anti-cancer metallo-drugs include serious toxicity and other side-effects,and major problems with resistance.New potent and selective anti-cancer drugs are urgently required.